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FDA limits use of Johnson & Johnson’s Covid-19 vaccine

May 5, 2022
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FDA limits use of Johnson & Johnson’s Covid-19 vaccine
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The Meals and Drug Administration on Thursday introduced it was limiting entry to Johnson & Johnson’s Covid-19 vaccine due to the chance of a blood clotting dysfunction that was found weeks after the vaccine was first put into use within the spring of 2021.

Going ahead, the single-dose vaccine will solely be accessible to folks 18 and older who can not take one of many different accessible vaccines for medical causes, or who merely is not going to conform to be vaccinated with one of many messenger RNA vaccines made by Moderna and by Pfizer and its associate BioNTech.

Peter Marks, the FDA’s vaccines lead, instructed STAT the company reached its resolution after a current evaluation of the info on the vaccine revealed one other individual on this nation had died after receiving it — the ninth such dying — within the first quarter of the yr. The vaccine is made by J&J’s vaccines division, Janssen.

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“If we see deaths and there may be another vaccine that’s not related to deaths however is related to related efficacy … we felt it was time at this level to make an announcement on the [product’s] reality sheet that this was not a first-line vaccine,” stated Marks, who’s director of the FDA’s Heart for Biologics Analysis and Analysis.


The clotting dysfunction, known as thrombosis with thrombocytopenia or TTS, is uncommon, occurring at a charge of about 3.25 instances per million doses administered. However the situation could be deadly or life-altering if a person survives. With one dying for each 2 million doses given on this nation, the FDA determined that may be a threat most individuals don’t have to take, Marks stated.

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The prospect of a single-dose vaccine held huge promise when J&J introduced its strategy. The vaccine doesn’t require the sophisticated chilly chain wanted for the mRNA vaccines. A single-dose product is enticing to individuals who don’t wish to be vaccinated, and cheaper to make use of for low- and middle-income international locations.

However the degree of safety the vaccine supplied was not as excessive as that induced by the messenger RNA and within the U.S., individuals who obtained the J&J vaccine have since been urged to get mRNA boosters. When the clotting threat was recognized in mid-April of 2021, the FDA paused use of the vaccine. Although the pause was lifted 10 days later, confidence within the vaccine had been shaken and demand for it plummeted.

In December, the unbiased panel that advises the Facilities for Illness Management and Prevention on vaccines issued a preferential suggestion for the mRNA vaccines over the J&J product.

Of the 577 million doses of Covid vaccine administered in the US, solely 18.7 million have been the J&J vaccine.

The corporate stated it has up to date its product sheet to replicate the FDA’s restrictions. In an announcement, it stated knowledge proceed to indicate that the advantages of the vaccine outweigh its dangers, when in comparison with going unvaccinated.

“Johnson & Johnson continues to collaborate with well being authorities and regulators around the globe to make sure healthcare professionals and people are warned and totally knowledgeable about reviews of TTS, enabling right analysis, applicable therapy, and expedited reporting,” it stated.

Marks confused that individuals who obtained the J&J vaccine up to now don’t want to fret. TTS, when it happens, develops per week or two after vaccination. Individuals who have been vaccinated months in the past will not be at risk of creating the situation, he stated.

He acknowledged the most recent announcement gained’t change a lot on the bottom in the US, the place few vaccination websites inventory the J&J vaccine at this level. But it surely may have implications overseas, the place international locations nonetheless struggling to vaccinate their populaces may very well be influenced by the U.S. resolution.

“In the US, that is most likely not going to have that a lot of an impact,” Marks stated. “We’re making an attempt to be cautious and we’ve knowledgeable our international companions at [the World Health Organization] as an example, about this and tried to work with them as a result of we don’t need our international companions to be panicked.”

“We’re not saying that it’s a nasty vaccine. We’re simply saying that for our inhabitants, the place there’s another, we really feel that the choice must be used.”



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